Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11938788 | 0.83 | IGF1R (0.45) | IGF1RNTRK1 | |
| SCHEMBL12439398 | 0.81 | IGF1R (0.53) | IGF1R | |
| SCHEMBL14050575 | 0.80 | IGF1R (0.53) | IGF1R | |
| SCHEMBL11338826 | 0.79 | IGF1R (0.74) | IGF1R | |
| SCHEMBL12439783 | 0.79 | IGF1R (0.51) | IGF1R | |
| SCHEMBL12438554 | 0.79 | IGF1R (0.49) | IGF1RNTRK1 | |
| SCHEMBL14161981 | 0.77 | IGF1R (0.53) | IGF1R | |
| SCHEMBL14161988 | 0.76 | IGF1R (0.67) | IGF1RNTRK1 | |
| SCHEMBL12439767 | 0.75 | IGF1R (0.58) | IGF1R | |
| SCHEMBL11343050 | 0.73 | IGF1R (0.70) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |