SCHEMBL12438734

SCHEMBL12438734

COc1ccc(C(C)(C)c2ccc(OC(C)=O)c(Cl)c2)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.45
CYP2C19 P33261 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
GAA P10253 2/20 0.44
ALDH1A1 P00352 2/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 2/20 0.43
TP53 P04637 1/20 0.43
PKM P14618 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TNFSF11 O14788 1/20 0.42
NR3C1 P04150 1/20 0.42
JUN P05412 1/20 0.41
NFKB1 P19838 1/20 0.41
POLB P06746 1/20 0.41
PTGS1 P23219 1/20 0.40
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12438737 0.93 TSHR (0.42) TSHRCYP2C19NPSR1GAAALDH1A1
SCHEMBL13163893 0.90 POLB (0.44) TSHRCYP2C19NPSR1GAAALDH1A1
SCHEMBL14181285 0.84 KMT2A (0.47) CYP2C19NPSR1GAAALDH1A1LMNA
SCHEMBL17049746 0.83 TSHR (0.57) TSHRCYP2C19GAAALDH1A1MAPT
SCHEMBL13161754 0.82 KMT2A (0.47) CYP2C19ALDH1A1LMNAMAPTHPGD
SCHEMBL2608608 0.81 TSHR (0.47) TSHRCYP2C19GAAALDH1A1HPGD
SCHEMBL10015729 0.80 TSHR (0.46) TSHRCYP2C19GAAALDH1A1HPGD
SCHEMBL5769694 0.80 KDM4E (0.60) CYP2C19ALDH1A1HPGDKDM4EUSP2
SCHEMBL13163891 0.79 LMNA (0.47) TSHRCYP2C19ALDH1A1LMNAHPGD
SCHEMBL17791828 0.78 BACE1 (0.47) TSHRNPSR1HPGDTP53PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8396399-B2 Toner bearing member, developing device, image forming apparatus, and image forming method RICOH COMPANY, LTD. (JP) 2013-03-12 US disclosed
US-8369755-B2 Developing device and image forming apparatus using the developing device RICOH COMPANY, LTD. (JP) 2013-02-05 US disclosed
US-20110176835-A1 TONER BEARING MEMBER, DEVELOPMENT DEVICE, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD (JP) 2011-07-21 US disclosed
US-20100329748-A1 DEVELOPING DEVICE AND IMAGE FORMING APPARATUS USING THE DEVELOPING DEVICE RICOH COMPANY, LTD. (JP) 2010-12-30 US disclosed
US-20100303509-A1 Toner Bearing Member, Developing Device, Image Forming Apparatus, And Image Forming Method RICOH COMPANY, LTD. (JP) 2010-12-02 US disclosed
US-7803507-B2 Electrophotographic photoreceptor and image forming apparatus including the same SHARP KABUSHIKI KAISHA (JP) 2010-09-28 US disclosed
US-7183027-B2 Image forming method FUJI XEROX CO., LTD. (JP) 2007-02-27 US disclosed
US-20070026334-A1 Electrophotographic photoreceptor and image forming apparatus including the same SHARP KABUSHIKI KAISHA (JP) 2007-02-01 US disclosed
US-7160659-B2 Electrophotographic apparatus and process cartridge CANON KABUSHIKI KAISHA (JP) 2007-01-09 US disclosed