⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944644 | 0.75 | ALDH1A1 (0.35) | — | |
| SCHEMBL945265 | 0.69 | TSHR (0.36) | — | |
| SCHEMBL28132806 | 0.69 | — | — | |
| SCHEMBL7119977 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL20873220 | 0.66 | TSHR (0.37) | — | |
| SCHEMBL1915862 | 0.66 | ARG2 (0.47) | — | |
| SCHEMBL409753 | 0.63 | TSHR (0.41) | — | |
| SCHEMBL12191378 | 0.63 | TSHR (0.41) | — | |
| SCHEMBL176426 | 0.63 | TSHR (0.41) | — | |
| SCHEMBL13642563 | 0.63 | CAMK2A (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324974-A1 | METHOD FOR PREPARING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS | 2016-11-10 | — | — | US | disclosed |
| US-9399070-B2 | Compositions comprising a polymeric reagent and a pharmacologically active agent | NEKTAR THERAPEUTICS (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150328331-A1 | Compositions Comprising a Polymeric Reagent and a Pharmacologically Active Agent | NEKTAR THERAPEUTICS (US) | 2015-11-19 | — | — | US | disclosed |
| US-9044516-B2 | Pharmaceutical compositions of conjugates formed from polymer derivatives having particular atom arrangements | NEKTAR THERAPEUTICS (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140227218-A1 | Pharmaceutical Compositions of Conjugates Formed From Polymer Derivatives Having Particular Atom Arrangements | NEKTAR THERAPEUTICS (US) | 2014-08-14 | — | — | US | disclosed |
| US-8633277-B2 | Methods for forming polymer-drug conjugates | NEKTAR THERAPEUTICS (US) | 2014-01-21 | — | — | US | disclosed |
| US-20110178242-A1 | Methods for Forming Polymer-Drug Conjugates | NEKTAR THERAPEUTICS (US) | 2011-07-21 | — | — | US | disclosed |
| US-7947261-B2 | Moiety is positioned between a water-soluble polymer and a reactive group; water soluble polymer such as polyethylene glycol containing a urethane linkage moiety for example, and a reactive group for conjugating with biodrugs | NEKTAR THERAPEUTICS (US) | 2011-05-24 | — | — | US | disclosed |
| US-7887789-B2 | Polymer derivatives having particular atom arrangements | NEKTAR THERAPEUTICS (US) | 2011-02-15 | — | — | US | disclosed |