Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050386 | 0.91 | IGF1R (0.49) | IGF1RHTR6 | |
| SCHEMBL12438570 | 0.85 | IGF1R (0.52) | IGF1R | |
| SCHEMBL14161981 | 0.79 | IGF1R (0.53) | IGF1RHTR6 | |
| SCHEMBL1791382 | 0.78 | IGF1R (0.77) | IGF1RHTR6 | |
| SCHEMBL14050578 | 0.77 | IGF1R (0.68) | IGF1R | |
| SCHEMBL14320002 | 0.75 | IGF1R (0.49) | IGF1R | |
| SCHEMBL14162124 | 0.75 | IGF1R (0.49) | IGF1R | |
| SCHEMBL12438231 | 0.74 | IGF1R (0.42) | IGF1R | |
| SCHEMBL12439839 | 0.73 | IGF1R (0.53) | IGF1R | |
| SCHEMBL14050611 | 0.72 | IGF1R (0.46) | IGF1RHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |