Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14162124 | 0.91 | IGF1R (0.49) | IGF1RAURKAAURKB | |
| SCHEMBL14050704 | 0.82 | IGF1R (0.48) | IGF1RAURKAAURKB | |
| SCHEMBL12439393 | 0.79 | IGF1R (0.49) | IGF1RAURKAAURKB | |
| SCHEMBL11343975 | 0.79 | IGF1R (0.76) | IGF1RAURKA | |
| SCHEMBL14320042 | 0.78 | IGF1R (0.50) | IGF1RAURKAJAK3JAK2PKM | |
| SCHEMBL12438570 | 0.77 | IGF1R (0.52) | IGF1R | |
| SCHEMBL12439829 | 0.76 | IGF1R (0.52) | IGF1RAURKAJAK3JAK2AURKB | |
| SCHEMBL12438231 | 0.76 | IGF1R (0.42) | IGF1R | |
| SCHEMBL12439403 | 0.75 | IGF1R (0.49) | IGF1R | |
| SCHEMBL12439798 | 0.74 | IGF1R (0.65) | IGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |