Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12438622 | 0.92 | CHRNB2 (0.40) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL3478940 | 0.84 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL13998791 | 0.84 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL12440387 | 0.83 | CHRNB2 (0.38) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL12438640 | 0.82 | CHRNB2 (0.45) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL14648511 | 0.82 | CHRNB2 (0.45) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL720947 | 0.81 | CHRNB2 (0.47) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL12966011 | 0.81 | CHRNB2 (0.40) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL12438620 | 0.80 | CHRNB2 (0.41) | CHRNB2CHRNA4MAPTKDM4EPOLB | |
| SCHEMBL719765 | 0.79 | DRD2 (0.44) | CHRNB2CHRNA4MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532665-B1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XUANZHU PHARMA CO LTD (CN) | 2016-09-07 | — | — | EP | disclosed |
| EP-2532665-A1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011095057-A1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 山东轩竹医药科技有限公司 (CN) | 2011-08-11 | — | — | WO | disclosed |