Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.46 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245477 | 1.00 | HDAC1 (0.47) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1246389 | 0.94 | HDAC1 (0.49) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1244303 | 0.94 | HDAC1 (0.49) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1246051 | 0.94 | HDAC1 (0.49) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1245469 | 0.94 | HDAC1 (0.49) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1244196 | 0.92 | BDKRB2 (0.48) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1246469 | 0.91 | MCHR1 (0.47) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1245391 | 0.91 | HDAC1 (0.50) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1244199 | 0.90 | LTA4H (0.41) | HDAC1HDAC4TRPV1HDAC3HDAC7 | |
| SCHEMBL1245392 | 0.90 | ACP1 (0.49) | HDAC1HDAC4TRPV1HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893020-B2 | can be coadministered with antimicrobial agents for treatment of infections caused by drug resistant bacteria; 2-Amino-N-{4-Amino-1-[-3-phenyl-1-(R)-(quinolin-3-ylcarbomoyl)-propylcarbamoyl]-butyl}succinamic acid; 2,5-Diamino-pentanoic acid [3-phenyl-1-(R)-(4-phenyl-thiazol-2-ylcarbamoyl)-propyl]-amide | MPEX PHARMACEUTICALS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7879795-B2 | can be coadministered with antimicrobial agents for treatment of infections caused by drug resistant bacteria; 2-Amino-N-{4-Amino-1-[-3-phenyl-1-(R)-(quinolin-3-ylcarbomoyl)-propylcarbamoyl]-butyl}succinamic acid; 2,5-Diamino-pentanoic acid [3-phenyl-1-(R)-(4-phenyl-thiazol-2-ylcarbamoyl)-propyl]-amide | MPEX PHARMACEUTICALS, INC. (US) | 2011-02-01 | — | — | US | disclosed |