Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.73 |
| ▸ | KIT | P10721 | 3/20 | 0.73 |
| ▸ | KDR | P35968 | 3/20 | 0.73 |
| ▸ | FLT3 | P36888 | 3/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.73 |
| ▸ | FLT1 | P17948 | 2/20 | 0.73 |
| ▸ | MST1R | Q04912 | 2/20 | 0.73 |
| ▸ | AXL | P30530 | 2/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | CHUK | O15111 | 1/20 | 0.73 |
| ▸ | MUSK | O15146 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.73 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580161 | 1.00 | MET (0.73) | METKITKDRFLT3PDGFRB | |
| SCHEMBL29693457 | 0.94 | MET (0.73) | METKITKDRFLT3PDGFRB | |
| SCHEMBL372005 | 0.94 | MET (0.73) | METKITKDRFLT3PDGFRB | |
| SCHEMBL372006 | 0.94 | MET (0.73) | METKITKDRFLT3PDGFRB | |
| SCHEMBL29693469 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB | |
| SCHEMBL372156 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB | |
| SCHEMBL19373139 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB | |
| SCHEMBL4405592 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB | |
| SCHEMBL29693456 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB | |
| SCHEMBL371942 | 0.93 | MET (0.85) | METKITKDRFLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |