Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.85 |
| ▸ | FLT3 | P36888 | 4/20 | 0.85 |
| ▸ | KDR | P35968 | 2/20 | 0.85 |
| ▸ | AXL | P30530 | 2/20 | 0.85 |
| ▸ | PLK4 | O00444 | 1/20 | 0.85 |
| ▸ | STK25 | O00506 | 1/20 | 0.85 |
| ▸ | CIT | O14578 | 1/20 | 0.85 |
| ▸ | AURKA | O14965 | 1/20 | 0.85 |
| ▸ | CHUK | O15111 | 1/20 | 0.85 |
| ▸ | MUSK | O15146 | 1/20 | 0.85 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.85 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.85 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.85 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.85 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.85 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.85 |
| ▸ | JAK2 | O60674 | 1/20 | 0.85 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.85 |
| ▸ | PAK3 | O75914 | 1/20 | 0.85 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371942 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL19373139 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL29693456 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL372157 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL372156 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL29693469 | 1.00 | MET (0.85) | METFLT3KDRAXLPLK4 | |
| SCHEMBL20216838 | 0.94 | MET (0.75) | METFLT3KDRAXLPLK4 | |
| SCHEMBL15580161 | 0.93 | MET (0.73) | METFLT3KDRAXLPLK4 | |
| SCHEMBL12443865 | 0.93 | MET (0.73) | METFLT3KDRAXLPLK4 | |
| SCHEMBL372006 | 0.93 | MET (0.73) | METFLT3KDRAXLPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178532-B2 | c-Met modulators and method of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-7579473-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20090170896-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2009-07-02 | — | — | US | disclosed |
| US-20070225307-A1 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170896-A1 | c-Met modulators and methods of use | FLT4, MET, FLT1 | MET 2/4885FLT3 7/4885KDR 5/4885 |
| US-20070225307-A1 | C-MET MODULATORS AND METHOD OF USE | FLT4, MET, FLT1 | MET 2/4885FLT3 7/4885KDR 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.