Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.42 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.42 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243786 | 0.96 | PIP4K2C (0.49) | PIP4K2CDNMT1DNMT3AALDH1A1CYP1A2 | |
| SCHEMBL1244782 | 0.93 | PIP4K2C (0.57) | PIP4K2CDNMT1DNMT3AALDH1A1CYP1A2 | |
| SCHEMBL1243893 | 0.93 | PIP4K2C (0.51) | PIP4K2CALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1244720 | 0.92 | ALDH1A1 (0.48) | PIP4K2CALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1244342 | 0.89 | CYP1A2 (0.47) | PIP4K2CALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28621552 | 0.89 | PIP4K2C (0.46) | PIP4K2CDNMT1DNMT3AALDH1A1CYP1A2 | |
| SCHEMBL1244474 | 0.89 | CDK9 (0.46) | PIP4K2CDNMT1DNMT3AALDH1A1TSHR | |
| SCHEMBL1243659 | 0.88 | PIP4K2C (0.43) | PIP4K2CALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4375146 | 0.88 | PIP4K2C (0.46) | PIP4K2CDNMT1DNMT3AALDH1A1CYP1A2 | |
| SCHEMBL1244614 | 0.87 | PIP4K2C (0.44) | PIP4K2CDNMT1DNMT3AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879853-B2 | tyrosisne kinase inhibitors such as N-[4-(6-Dibenzofuran-4-yl-pyrimidin-4-ylamino)-phenyl]-4-morpholin-4-yl-benzamide, used as anticasrcinogenic or antoproliferative agents, especially in the treatment of breast cancer | BAYER SCHERING PHARMA AG (DE) | 2011-02-01 | — | — | US | claimed |
| EP-1763526-B1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2009-06-24 | — | — | EP | claimed |
| EP-1763526-B1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2009-06-24 | — | — | EP | disclosed |
| EP-1763526-A1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Altana Pharma AG (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006000589-A1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ALTANA PHARMA AG (DE) | 2006-01-05 | — | — | WO | disclosed |