Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.79 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944986 | 0.92 | BACE1 (0.68) | BACE1BACE2APPCTSD | |
| SCHEMBL12445909 | 0.92 | BACE1 (0.68) | BACE1BACE2APP | |
| SCHEMBL7945396 | 0.92 | BACE1 (0.67) | BACE1BACE2APP | |
| SCHEMBL7946763 | 0.92 | BACE1 (0.66) | BACE1BACE2APPCTSD | |
| SCHEMBL12445787 | 0.92 | BACE1 (0.66) | BACE1BACE2APPCTSD | |
| SCHEMBL12445978 | 0.91 | BACE1 (0.65) | BACE1BACE2APPCTSD | |
| SCHEMBL7940563 | 0.90 | BACE1 (0.65) | BACE1BACE2APPCTSD | |
| SCHEMBL7945386 | 0.90 | BACE1 (0.78) | BACE1BACE2CTSD | |
| SCHEMBL7942895 | 0.89 | BACE1 (0.62) | BACE1BACE2APP | |
| SCHEMBL7942788 | 0.89 | BACE1 (0.65) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |