Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.66 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445787 | 0.93 | BACE1 (0.66) | BACE1BACE2APPPRKCICTSD | |
| SCHEMBL12445978 | 0.92 | BACE1 (0.65) | BACE1BACE2APPCTSD | |
| SCHEMBL12445909 | 0.92 | BACE1 (0.68) | BACE1BACE2APPPRKCI | |
| SCHEMBL7944986 | 0.92 | BACE1 (0.68) | BACE1BACE2APPPRKCICTSD | |
| SCHEMBL12445765 | 0.92 | BACE1 (0.79) | BACE1BACE2APPCTSD | |
| SCHEMBL7940563 | 0.90 | BACE1 (0.65) | BACE1BACE2APPPRKCICTSD | |
| SCHEMBL7945386 | 0.90 | BACE1 (0.78) | BACE1BACE2CTSD | |
| SCHEMBL7945035 | 0.88 | BACE1 (0.84) | BACE1BACE2APP | |
| SCHEMBL12302339 | 0.88 | BACE1 (0.66) | BACE1BACE2PRKCI | |
| SCHEMBL7942788 | 0.87 | BACE1 (0.65) | BACE1BACE2PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |