Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273520 | 0.88 | HTT (0.42) | HTTMAPTMAPK1SIGMAR1NOTUM | |
| SCHEMBL3558789 | 0.80 | UGCG (0.39) | MAPTCNR1CNR2SMN1; SMN2KDM4E | |
| SCHEMBL3558787 | 0.80 | UGCG (0.39) | MAPTCNR1CNR2SMN1; SMN2KDM4E | |
| SCHEMBL957550 | 0.74 | POLB (0.44) | HTTSIGMAR1KCNH2SMN1; SMN2 | |
| SCHEMBL957552 | 0.74 | POLB (0.44) | HTTSIGMAR1KCNH2SMN1; SMN2 | |
| SCHEMBL957553 | 0.74 | POLB (0.44) | HTTSIGMAR1KCNH2SMN1; SMN2 | |
| SCHEMBL960002 | 0.72 | ALDH1A1 (0.47) | HTTMAPK1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL960003 | 0.72 | ALDH1A1 (0.47) | HTTMAPK1SMN1; SMN2KDM4ENPSR1 | |
| Oxalic Acid SCHEMBL956172 | 0.71 | SIGMAR1 (0.40) | HTTSIGMAR1KCNH2CNR1CNR2 | |
| Oxalic Acid SCHEMBL956174 | 0.71 | SIGMAR1 (0.40) | HTTSIGMAR1KCNH2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781619-B1 | SIGMA RECEPTOR INHIBITORS | ESTEVE LABOR DR (ES) | 2011-08-17 | — | — | EP | disclosed |