Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12448907 | 0.87 | IDO1 (0.45) | IDO1CYP3A4EPHX1HTTPYCR1 | |
| SCHEMBL12575211 | 0.84 | SLC6A2 (0.49) | IDO1CYP3A4EPHX1HTTPYCR1 | |
| SCHEMBL2263360 | 0.80 | IDO1 (0.42) | IDO1CYP3A4EPHX1HTTALDH1A1 | |
| SCHEMBL10098876 | 0.74 | TAAR1 (0.47) | IDO1CYP3A4PYCR1SLC6A2SLC6A4 | |
| SCHEMBL11454882 | 0.72 | PYCR1 (0.45) | IDO1CYP3A4EPHX1HTTTDP1 | |
| SCHEMBL10098874 | 0.72 | ROCK1 (0.48) | CYP3A4HTTALDH1A1 | |
| SCHEMBL28267899 | 0.71 | IDO1 (0.46) | IDO1CYP3A4EPHX1HTTALDH1A1 | |
| Chlorbetamide SCHEMBL30482548 | 0.71 | IDO1 (0.43) | IDO1CYP3A4EPHX1ALDH1A1L3MBTL1 | |
| Chlorbetamide SCHEMBL932741 | 0.71 | IDO1 (0.43) | IDO1CYP3A4EPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL260323 | 0.70 | L3MBTL1 (0.55) | IDO1EPHX1HTTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173723-B1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-08-31 | — | — | EP | disclosed |