SCHEMBL124512

SCHEMBL124512

Cc1ccc2c(c1)C(=O)N(CC(=O)O)C2=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 1/20 0.73
LPAR3 Q9UBY5 1/20 0.73
TDP1 Q9NUW8 2/20 0.64
CA12 O43570 2/20 0.62
CA9 Q16790 2/20 0.62
CHRM2 P08172 2/20 0.54
KMT2A Q03164 2/20 0.53
CA1 P00915 1/20 0.53
SMN1; SMN2 Q16637 3/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
MAPT P10636 1/20 0.50
AKR1B1 P15121 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
HTT P42858 1/20 0.49
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10584655 0.85 LPAR1 (0.55) LPAR1LPAR3TDP1CA12CA9
SCHEMBL20846409 0.85 LPAR3 (1.00) LPAR1LPAR3TDP1CA12CA9
SCHEMBL25669461 0.82 LPAR1 (0.56) LPAR1LPAR3CHRM2KMT2ASMN1; SMN2
SCHEMBL13903462 0.80 CHRM2 (0.57) LPAR1LPAR3CA12CA9CHRM2
SCHEMBL21389366 0.79 LPAR1 (0.50) LPAR1LPAR3CA12CA9CHRM2
SCHEMBL15502147 0.79 POLB (0.71) LPAR1LPAR3TDP1CA12CA9
SCHEMBL13187734 0.79 HSD17B10 (0.68) LPAR1LPAR3TDP1CA12CA9
SCHEMBL13187313 0.79 TDP1 (0.64) LPAR1LPAR3TDP1CA12CA9
SCHEMBL4234864 0.79 POLB (0.71) LPAR1LPAR3TDP1CA12CA9
SCHEMBL523580 0.79 TDP1 (0.64) LPAR1LPAR3TDP1CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8461267-B2 Propylene polymers with improved properties BOREALIS AG (AT) 2013-06-11 US claimed
US-8394475-B2 Industrial polyolefin piping system BOREALIS TECHNOLOGY OY (FI) 2013-03-12 US claimed
US-8389089-B2 Propylene polymer pipes for pipelines BOREALIS TECHNOLOGY OY (FI) 2013-03-05 US claimed
US-20120302680-A1 PROPYLENE POLYMERS WITH IMPROVED PROPERTIES BOREALIS TECHNOLOGY OY (FI) 2012-11-29 US claimed
US-20110132478-A1 INDUSTRIAL POLYOLEFIN PIPING SYSTEM BOREALIS TECHNOLOGY OY (FI) 2011-06-09 US claimed
US-20110123751-A1 PROPYLENE POLYMER PIPES FOR PIPELINES BOREALIS TECHNOLOGY OY (FI) 2011-05-26 US claimed
US-20100305246-A1 PROPYLENE POLYMERS WITH IMPROVED PROPERTIES BOREALIS TECHNOLOGY OY (FI) 2010-12-02 US claimed
EP-1399505-B1 INDUSTRIAL POLYOLEFIN PIPING SYSTEM BOREALIS TECH OY (FI) 2010-07-21 EP claimed
US-7294642-B2 1,3-Diamino-2-hydroxypropane pro-drug derivatives ELAN PHARMACEUTICALS, INC. (US) 2007-11-13 US claimed
EP-1401894-B1 PROPYLENE POLYMERS WITH IMPROVED PROPERTIES BOREALIS TECH OY (FI) 2006-07-19 EP claimed
US-20040158002-A1 Propylene polymers with improved properties BOREALIS AG (AT) 2004-08-12 US claimed
EP-1401893-A1 PROPYLENE POLYMER PIPES FOR PIPELINES Borealis Technology OY (FI) 2004-03-31 EP claimed
EP-1401894-A1 PROPYLENE POLYMERS WITH IMPROVED PROPERTIES Borealis Technology OY (FI) 2004-03-31 EP claimed
EP-1399505-A1 INDUSTRIAL POLYOLEFIN PIPING SYSTEM Borealis Technology OY (FI) 2004-03-24 EP claimed
WO-2002094923-A1 INDUSTRIAL POLYOLEFIN PIPING SYSTEM BOREALIS TECHNOLOGY OY (FI) 2002-11-28 WO claimed
WO-2002094894-A1 PROPYLENE POLYMERS WITH IMPROVED PROPERTIES BOREALIS TECHNOLOGY OY (FI) 2002-11-28 WO claimed
WO-2002094895-A1 PROPYLENE POLYMER PIPES FOR PIPELINES BOREALIS TECHNOLOGY OY (FI) 2002-11-28 WO claimed
EP-1260529-A1 Propylene polymers with improved properties Borealis Technology OY (FI) 2002-11-27 EP claimed
EP-1260545-A1 Industrial polyolefin piping system Borealis Technology OY (FI) 2002-11-27 EP claimed
EP-1260528-A1 Propylene polymer pipes for pipelines Borealis Technology OY (FI) 2002-11-27 EP claimed