Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247418 | 0.90 | LPAR1 (0.48) | LPAR1SCN9AENPP2NPSR1LPAR3 | |
| SCHEMBL1247197 | 0.87 | NTRK1 (0.41) | LPAR1SCN9AENPP2NPSR1SCN5A | |
| SCHEMBL1247169 | 0.86 | MGLL (0.52) | LPAR1SCN9AENPP2NPSR1SCN5A | |
| SCHEMBL2338531 | 0.86 | LPAR1 (0.61) | LPAR1ENPP2LPAR3LPAR2MGLL | |
| SCHEMBL1247293 | 0.84 | SCN9A (0.52) | LPAR1SCN9AENPP2NPSR1LPAR3 | |
| SCHEMBL1246325 | 0.83 | SCN9A (0.46) | LPAR1SCN9AENPP2NPSR1LPAR3 | |
| SCHEMBL11895499 | 0.82 | LPAR1 (0.61) | LPAR1SCN9ANPSR1LPAR3LPAR2 | |
| SCHEMBL1245362 | 0.82 | SCN9A (0.57) | LPAR1SCN9ANPSR1LPAR3LPAR2 | |
| SCHEMBL1247570 | 0.81 | SCN9A (0.46) | LPAR1SCN9AENPP2NPSR1LPAR3 | |
| SCHEMBL1245272 | 0.81 | SCN9A (0.45) | LPAR1SCN9AENPP2NPSR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |