Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13817550 | 0.82 | DPP4 (0.43) | DPP4ALDH1A1ABCB1ABCG2SMN1; SMN2 | |
| SCHEMBL14182486 | 0.82 | DPP4 (0.44) | DPP4ALDH1A1ABCB1ABCG2GAA | |
| SCHEMBL3150091 | 0.80 | DPP4 (0.42) | DPP4SMN1; SMN2 | |
| SCHEMBL13035720 | 0.79 | SMN1; SMN2 (0.46) | DPP4ALDH1A1GAAMAPK1SMN1; SMN2 | |
| SCHEMBL1713675 | 0.79 | DPP4 (0.41) | DPP4ALDH1A1ABCB1ABCG2SMN1; SMN2 | |
| SCHEMBL2273553 | 0.77 | DPP4 (0.40) | DPP4ALDH1A1ABCB1ABCG2MAPK1 | |
| Hydrochloric Acid SCHEMBL2275641 | 0.76 | DPP4 (0.40) | DPP4ALDH1A1ABCB1ABCG2MAPK1 | |
| SCHEMBL12019703 | 0.75 | ALDH1A1 (0.38) | DPP4ALDH1A1GAAHSD17B10MAPK1 | |
| SCHEMBL14213173 | 0.75 | ALDH1A1 (0.38) | DPP4ALDH1A1GAAHSD17B10MAPK1 | |
| SCHEMBL23083016 | 0.75 | DPP4 (0.50) | DPP4ALDH1A1GAAHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814822-B1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | claimed |
| WO-2013120921-A9 | NOVEL PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | claimed |
| EP-2814822-A1 | NOVEL PYRROLIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-24 | — | — | EP | claimed |
| US-8802665-B2 | Pyrrolidine derivatives | GENENTECH, INC. (US) | 2014-08-12 | — | — | US | claimed |
| US-20130217665-A1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-08-22 | — | — | US | claimed |
| WO-2013120921-A1 | NOVEL PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-22 | — | — | WO | claimed |
| EP-2814822-B1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| WO-2013120921-A9 | NOVEL PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | disclosed |
| EP-2814822-A1 | NOVEL PYRROLIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-24 | — | — | EP | disclosed |
| US-8802665-B2 | Pyrrolidine derivatives | GENENTECH, INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130217665-A1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-08-22 | — | — | US | disclosed |
| WO-2013120921-A1 | NOVEL PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-22 | — | — | WO | disclosed |
| WO-2011101304-A2 | PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217665-A1 | NOVEL PYRROLIDINE DERIVATIVES | PYCR1, ADCYAP1R1, AVPR1A | DPP4 2541/4885ALDH1A1 121/4885ABCB1 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.