SCHEMBL1245802

SCHEMBL1245802

COc1cc(CC(=O)c2c(O)cc(O)cc2O)ccc1O

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.83
HPGD P15428 3/20 0.83
MAPT P10636 3/20 0.83
MEN1 O00255 2/20 0.83
KMT2A Q03164 2/20 0.83
ALDH1A1 P00352 2/20 0.65
TSHR P16473 2/20 0.65
NFKB1 P19838 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
CYP19A1 P11511 1/20 0.58
MAPK1 P28482 2/20 0.56
PTPN1 P18031 2/20 0.56
CYP3A4 P08684 1/20 0.56
PIK3CA P42336 1/20 0.56
SLC5A1 P13866 1/20 0.55
SLC5A2 P31639 1/20 0.55
ALOX5 P09917 1/20 0.52
OR51E2 Q9H255 1/20 0.52
USP2 O75604 1/20 0.52
LMNA P02545 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29535946 1.00 GAA (0.83) GAAHPGDMAPTMEN1KMT2A
SCHEMBL3965268 0.88 GAA (0.83) GAAHPGDMAPTMEN1KMT2A
SCHEMBL16389390 0.87 GAA (0.64) GAAHPGDMAPTMEN1KMT2A
SCHEMBL31511911 0.85 CYP19A1 (0.80) GAAHPGDMAPTMEN1KMT2A
SCHEMBL1841469 0.85 CYP19A1 (0.80) GAAHPGDMAPTMEN1KMT2A
SCHEMBL18324967 0.84 GAA (0.60) GAAHPGDMAPTMEN1KMT2A
SCHEMBL29535974 0.82 MEN1 (0.70) GAAHPGDMAPTMEN1KMT2A
SCHEMBL1245832 0.82 MEN1 (0.70) GAAHPGDMAPTMEN1KMT2A
SCHEMBL28447398 0.81 GAA (0.69) GAAHPGDMAPTMEN1KMT2A
SCHEMBL1224101 0.81 SLC5A1 (0.75) GAAHPGDMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 250 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3383200-B1 COMPOSITIONS SYMRISE AG (DE) 2019-11-06 EP claimed
US-20190289886-A1 SUBSTANCE MIXTURES SYMRISE AG (DE) 2019-09-26 US claimed
EP-2386211-B1 USE OF RUBUSOSIDE TO REDUCE OR SUPPRESS PARTICULAR UNPLEASANT TASTE SENSATIONS SYMRISE AG (DE) 2016-08-10 EP claimed
EP-2386211-A1 Use of rubusoside to reduce or suppress particular unpleasant taste sensations Symrise AG (DE) 2011-11-16 EP claimed
US-8041053-B2 Vehicular sound effect generating apparatus HONDA MOTOR CO., LTD. (JP) 2011-10-18 US claimed
WO-2011024197-A1 PROCESS FOR PRODUCING A REDUCED BULK DENSITY SUCRALOSE CONTAINING SWEETENER SYSTEM AND PRODUCTS THEREOF V.B. MEDICARE PVT. LTD. (IN) 2011-03-03 WO claimed
EP-1868452-B1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE SYMRISE GMBH & CO KG (DE) 2009-07-22 EP claimed
EP-2008530-A1 Aroma composition for reducing or suppressing unwanted bitter and astringent impressions Symrise GmbH & Co. KG (DE) 2008-12-31 EP claimed
US-20080317923-A1 AROMA COMPOSITION FOR REDUCING OR SUPPRESSING AN UNDESIRED BITTER, ASTRINGENT IMPRESSION SYMRISE GMBH & CO. KG (DE) 2008-12-25 US claimed
EP-2001448-A2 FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE Cadbury Adams USA LLC (US) 2008-12-17 EP claimed
US-20080113073-A1 Hydroxydeoxybenzoins And The Use Thereof to Mask A Bitter Taste SYMRISE GMBH & CO. KG (DE) 2008-05-15 US claimed
EP-1868452-A1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE Symrise GmbH & Co. KG (DE) 2007-12-26 EP claimed
WO-2007089652-A2 FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE CADBURY ADAMS USA LLC (US) 2007-08-09 WO claimed
US-20070178123-A1 FLAVOR-ENHANCING COMPOSITIONS, METHOD OF MANUFACTURE, AND METHODS OF USE KRAFT FOODS GLOBAL BRANDS LLC 2007-08-02 US claimed
WO-2006106023-A1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE SYMRISE GMBH & CO. KG (DE) 2006-10-12 WO claimed
EP-3454825-B1 AROMA PREPARATIONS CONTAINING MENTHOL SYMRISE AG (DE) 2026-05-06 EP disclosed
EP-3911172-B1 COMBINATION OF SATIETY COMPONENTS WITH ARGININE SYMRISE AG (DE) 2026-04-15 EP disclosed
WO-2007014879-A1 USE OF HESPERETIN FOR ENHANCING THE SWEET TASTE SYMRISE GMBH & CO. KG (DE) 2007-02-08 WO disclosed
WO-2007003527-A1 HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE SYMRISE GMBH & CO. KG (DE) 2007-01-11 WO disclosed
WO-2006106023-A1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE SYMRISE GMBH & CO. KG (DE) 2006-10-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190289886-A1 SUBSTANCE MIXTURES PNN, NISCH, HES1 GAA 423/4885HPGD 472/4885MAPT 654/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.