SCHEMBL1245974

SCHEMBL1245974

CCOC(=O)C=C(c1ccc(C#Cc2ccccc2)cc1)c1ccc(C#Cc2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 4/20 0.52
MMP9 P14780 4/20 0.52
MMP12 P39900 4/20 0.52
MMP14 P50281 1/20 0.52
MMP15 P51511 1/20 0.52
MMP16 P51512 1/20 0.52
MMP26 Q9NRE1 1/20 0.52
FFAR1 O14842 3/20 0.43
GAA P10253 1/20 0.43
VCP P55072 1/20 0.42
MAPT P10636 1/20 0.42
NPC1 O15118 2/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GRM5 P41594 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ACACB O00763 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744392 0.99 MMP2 (0.51) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1746516 0.93 MMP2 (0.50) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1746510 0.93 MMP2 (0.50) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1746507 0.93 MMP2 (0.50) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1070286 0.86 MEN1 (0.53) GAAMAPTNPC1RAB9ASMN1; SMN2
SCHEMBL1745367 0.85 GAA (0.39) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1745364 0.85 GAA (0.39) MMP2MMP9MMP12MMP14MMP15
SCHEMBL1745365 0.85 GAA (0.39) MMP2MMP9MMP12MMP14MMP15
SCHEMBL8999201 0.83 NPC1 (0.50) GAAMAPTNPC1HTTRAB9A
SCHEMBL8999208 0.83 NPC1 (0.50) GAAMAPTNPC1HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110039841-A1 Novel compounds, their preparation and use NOVO NORDISK A/S (DK) 2011-02-17 US disclosed
EP-1763511-B1 PHENOXYACETIC ACID DERIVATIVES AS PPAR AGONISTS HIGH POINT PHARMACEUTICALS LLC (US) 2010-07-28 EP disclosed
EP-1763511-A1 PHENOXYACETIC ACID DERIVATIVES AS PPAR AGONISTS NOVO NORDISK A/S (DK) 2007-03-21 EP disclosed
WO-2005105735-A1 PHENOXYACETIC ACID DERIVATIVES AS PPAR AGONISTS NOVO NORDISK A/S (DK) 2005-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110039841-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA MMP2 3343/4885MMP9 4089/4885MMP12 2994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.