Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL1245992

NCCC[C@H](N)C(=O)N[C@H](CCc1ccc(C(F)(F)F)cc1)C(=O)Nc1cnc2ccccc2c1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.46
HDAC4 P56524 5/20 0.46
MCHR1 Q99705 1/20 0.45
HDAC3 O15379 4/20 0.45
HDAC7 Q8WUI4 4/20 0.45
HDAC2 Q92769 4/20 0.45
HDAC10 Q969S8 4/20 0.45
HDAC11 Q96DB2 4/20 0.45
HDAC8 Q9BY41 4/20 0.45
HDAC6 Q9UBN7 4/20 0.45
HDAC9 Q9UKV0 4/20 0.45
HDAC5 Q9UQL6 4/20 0.45
TRPV1 Q8NER1 6/20 0.43
CNR1 P21554 2/20 0.42
CNR2 P34972 2/20 0.42
SCN9A Q15858 1/20 0.41
ADCY6 O43306 1/20 0.41
ADCY3 O60266 1/20 0.41
ADCY9 O60503 1/20 0.41
ADCY5 O95622 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1246469 0.97 MCHR1 (0.47) HDAC1HDAC4MCHR1HDAC3HDAC7
SCHEMBL1245446 0.91 BDKRB2 (0.46) HDAC1HDAC4MCHR1HDAC3HDAC7
SCHEMBL1245377 0.90 HDAC1 (0.40) HDAC1HDAC4MCHR1HDAC3HDAC7
SCHEMBL1246051 0.89 HDAC1 (0.49) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL1244303 0.89 HDAC1 (0.49) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL1246389 0.89 HDAC1 (0.49) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL1245469 0.89 HDAC1 (0.49) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL13365364 0.89 HDAC1 (0.46) HDAC1HDAC4MCHR1HDAC3HDAC7
SCHEMBL1244307 0.89 HDAC1 (0.47) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL1245477 0.89 HDAC1 (0.47) HDAC1HDAC4HDAC3HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7893020-B2 can be coadministered with antimicrobial agents for treatment of infections caused by drug resistant bacteria; 2-Amino-N-{4-Amino-1-[-3-phenyl-1-(R)-(quinolin-3-ylcarbomoyl)-propylcarbamoyl]-butyl}succinamic acid; 2,5-Diamino-pentanoic acid [3-phenyl-1-(R)-(4-phenyl-thiazol-2-ylcarbamoyl)-propyl]-amide MPEX PHARMACEUTICALS, INC. (US) 2011-02-22 US disclosed
US-7879795-B2 can be coadministered with antimicrobial agents for treatment of infections caused by drug resistant bacteria; 2-Amino-N-{4-Amino-1-[-3-phenyl-1-(R)-(quinolin-3-ylcarbomoyl)-propylcarbamoyl]-butyl}succinamic acid; 2,5-Diamino-pentanoic acid [3-phenyl-1-(R)-(4-phenyl-thiazol-2-ylcarbamoyl)-propyl]-amide MPEX PHARMACEUTICALS, INC. (US) 2011-02-01 US disclosed