Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1245397 | 0.97 | CNR2 (0.34) | CNR2MEN1KMT2AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7255521 | 0.83 | MEN1 (0.39) | MEN1KMT2AMTNR1AMTNR1BCYP2D6 | |
| SCHEMBL4435969 | 0.83 | TDP1 (0.47) | CYP1A2CYP2C9LMNA | |
| SCHEMBL6141911 | 0.76 | TDP1 (0.46) | CYP1A2CYP2C9LMNA | |
| SCHEMBL4559606 | 0.74 | MTNR1A (0.40) | CNR2MTNR1AMTNR1BIDH1ALDH1A1 | |
| SCHEMBL11459334 | 0.72 | MTNR1A (0.46) | CNR2MTNR1AMTNR1BCYP2D6CYP1A2 | |
| SCHEMBL4352157 | 0.70 | FLT3 (0.37) | CNR2MEN1KMT2AMTNR1AMTNR1B | |
| Nitric Acid SCHEMBL4352160 | 0.69 | CYP1A2 (0.40) | MEN1KMT2AMTNR1ACYP1A2CYP3A4 | |
| SCHEMBL5495433 | 0.69 | PTGS1 (0.47) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8859950 | 0.68 | MTNR1A (0.43) | MTNR1AMTNR1BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012400-A2 | NITRIC OXIDE RELEASING NAPROXEN | NICOX S.A. (FR) | 2011-02-03 | — | — | WO | disclosed |