Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL4559607 | 0.97 | CYP1A2 (0.40) | CYP1A2CYP2A6MEN1KMT2ARAPGEF3 | |
| SCHEMBL4559606 | 0.86 | MTNR1A (0.40) | LMNAPOLBMTNR1AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7255521 | 0.76 | MEN1 (0.39) | MEN1KMT2ALMNAMTNR1A | |
| Nitric Acid SCHEMBL28353393 | 0.75 | CYP1A2 (0.70) | CYP1A2CYP2A6MEN1KMT2ARAPGEF3 | |
| Nitric Acid SCHEMBL4027674 | 0.72 | PTGS2 (0.60) | CYP1A2MEN1KMT2ALMNAMAPT | |
| SCHEMBL4352157 | 0.71 | FLT3 (0.37) | MEN1KMT2ALMNAPOLBMTNR1A | |
| SCHEMBL7828216 | 0.71 | PTGS2 (0.44) | KMT2ALMNARAB9AALDH1A1HTT | |
| SCHEMBL10595586 | 0.71 | LMNA (0.54) | MEN1KMT2ALMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7828218 | 0.70 | PTGS2 (0.43) | KMT2ALMNARAB9AALDH1A1HTT | |
| SCHEMBL3651806 | 0.70 | PTGS2 (0.63) | CYP1A2MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154999-B1 | NITROXYDERIVATIVES HAVING ANTIINFLAMMATORY, ANALGESIC AND ANTITHROMBOTIC ACTIVITY | NICOX SA (FR) | 2009-04-15 | — | — | EP | disclosed |