Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14789496 | 0.81 | TSHR (0.40) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL28045902 | 0.79 | TSHR (0.39) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL28299844 | 0.75 | — | — | |
| SCHEMBL3065497 | 0.71 | TP53 (0.39) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL8804536 | 0.68 | TAAR1 (0.45) | TAAR1SMN1; SMN2 | |
| SCHEMBL12689696 | 0.67 | MGLL (0.37) | TSHRTDP1CHRM2CHRM5CHRM3 | |
| SCHEMBL3242474 | 0.67 | TSHR (0.40) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL11100474 | 0.67 | TSHR (0.40) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL9642844 | 0.66 | TSHR (0.52) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL8803735 | 0.66 | MEN1 (0.47) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088196-A2 | INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF | YALE UNIVERSITY (US) | 2011-07-21 | — | — | WO | disclosed |