Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365323 | 0.90 | HDAC6 (0.71) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL1365321 | 0.90 | HDAC6 (0.71) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL16474100 | 0.73 | HDAC6 (0.70) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL1367216 | 0.73 | HDAC1 (0.70) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL1367266 | 0.73 | HDAC6 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10742365 | 0.71 | HDAC2 (0.66) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10742359 | 0.71 | HDAC2 (0.66) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL10742353 | 0.71 | HDAC2 (0.66) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL459242 | 0.71 | HDAC2 (0.70) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL459244 | 0.71 | HDAC2 (0.70) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |