SCHEMBL459244

SCHEMBL459244

NNC(=O)C=Cc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 3/20 0.70
HDAC3 O15379 2/20 0.70
HDAC4 P56524 2/20 0.70
HDAC1 Q13547 2/20 0.70
HDAC8 Q9BY41 2/20 0.70
HDAC6 Q9UBN7 2/20 0.70
MMP1 P03956 6/20 0.63
MMP2 P08253 6/20 0.63
MMP9 P14780 6/20 0.63
EGFR P00533 4/20 0.63
MAOA P21397 1/20 0.63
MAOB P27338 1/20 0.63
HTT P42858 1/20 0.62
KMT2A Q03164 1/20 0.59
MAPT P10636 2/20 0.59
ALDH1A1 P00352 2/20 0.59
RECQL P46063 2/20 0.59
TNKS O95271 1/20 0.59
HCAR2 Q8TDS4 1/20 0.59
HDAC7 Q8WUI4 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL459242 1.00 HDAC2 (0.70) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL10742365 0.96 HDAC2 (0.66) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL10742359 0.96 HDAC2 (0.66) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL10742353 0.96 HDAC2 (0.66) HDAC2HDAC3HDAC4HDAC1HDAC8
Trifluoroacetic Acid SCHEMBL29399040 0.89 HDAC2 (0.58) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL31528739 0.89 MAPT (0.68) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL1325253 0.83 HDAC2 (1.00) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL4029206 0.83 HDAC2 (0.76) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL11704206 0.83 HDAC3 (0.76) HDAC2HDAC3HDAC4HDAC1HDAC8
SCHEMBL29060766 0.83 HDAC2 (0.76) HDAC2HDAC3HDAC4HDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110684002-B Acylhydrazone fluoride ion probe based on flavone 南京林业大学 2022-02-08 CN claimed
EP-3082974-B1 CARRIER SYSTEM FOR WATER-SOLUBLE ACTIVE INGREDIENTS OREAL (FR) 2020-02-05 EP claimed
CN-110684002-A Novel acylhydrazone fluoride ion probe based on flavone 南京林业大学 2020-01-14 CN claimed
WO-2007047394-A2 THIOTRIAZOLYL DERIVATIVES EPIX DELAWARE, INC. (US) 2007-04-26 WO claimed
US-20250324970-A1 ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF KODA THERAPEUTICS LLC (US) 2025-10-23 US disclosed
US-12369579-B2 Antimicrobial agents and compositions and uses thereof Koda Therapeutics, LLC (US) 2025-07-29 US disclosed
CN-116367809-A Skin care composition 莱雅公司 2023-06-30 CN disclosed
US-20220378044-A1 ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF CHEMIC LABORATORIES, LLC 2022-12-01 US disclosed
EP-4031128-A1 ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF Koda Therapeutics, LLC (US) 2022-07-27 EP disclosed
CN-110684002-B Acylhydrazone fluoride ion probe based on flavone 南京林业大学 2022-02-08 CN disclosed
CN-110684002-A Novel acylhydrazone fluoride ion probe based on flavone 南京林业大学 2020-01-14 CN disclosed
CN-109761941-A 2- (benzofuran -7- oxygroup)-N '-substituted aryl/alkyl acetoacetates hydazone derivative and the preparation method and application thereof 河北大学 2019-05-17 CN disclosed
US-7534905-B2 Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2009-05-19 US disclosed
EP-1480988-A4 REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS UNIV COLUMBIA (US) 2006-03-29 EP disclosed
US-20050288525-A1 Reagents for asymmetric allylation, aldol, and tandem aldol and allylation reactions NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-12-29 US disclosed
EP-1480988-A1 REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS The Trustees of Columbia University in the City of New York (US) 2004-12-01 EP disclosed
WO-2003074534-A9 REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS UNIV COLUMBIA (US) 2003-11-20 WO disclosed
WO-2003074534-A1 REAGENTS FOR ASYMMETRIC ALLYLATION, ALDOL, AND TANDEM ALDOL AND ALLYLATION REACTIONS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2003-09-12 WO disclosed
US-4065635-A ETHYLENE-PROPYLENE COPOLYMER, DISUBSTITUTED HYDRAZINE DART INDUSTRIES, INC. (US) 1977-12-27 US disclosed
US-4052362-A N-CINNAMOYL-N'-ACYLHYDRAZINES UBE INDUSTRIES, LTD. (JA) 1977-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12369579-B2 Antimicrobial agents and compositions and uses thereof MPO, PGC, CAT HDAC2 1516/4885HDAC3 1351/4885HDAC4 915/4885
US-20220378044-A1 ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF MPO, PGC, CAT HDAC2 1516/4885HDAC3 1351/4885HDAC4 915/4885
US-20050288525-A1 Reagents for asymmetric allylation, aldol, and tandem aldol and allylation reactions AKR1C3, AKR1B10, CBR3 HDAC2 2800/4885HDAC3 2222/4885HDAC4 4178/4885
US-20250324970-A1 ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF MPO, PGC, CAT HDAC2 1516/4885HDAC3 1351/4885HDAC4 915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.