Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.70 |
| ▸ | MMP1 | P03956 | 6/20 | 0.63 |
| ▸ | MMP2 | P08253 | 6/20 | 0.63 |
| ▸ | MMP9 | P14780 | 6/20 | 0.63 |
| ▸ | EGFR | P00533 | 4/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459244 | 1.00 | HDAC2 (0.70) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL10742365 | 0.96 | HDAC2 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL10742359 | 0.96 | HDAC2 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL10742353 | 0.96 | HDAC2 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| Trifluoroacetic Acid SCHEMBL29399040 | 0.89 | HDAC2 (0.58) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL31528739 | 0.89 | MAPT (0.68) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL1325253 | 0.83 | HDAC2 (1.00) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL4029206 | 0.83 | HDAC2 (0.76) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL11704206 | 0.83 | HDAC3 (0.76) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL29060766 | 0.83 | HDAC2 (0.76) | HDAC2HDAC3HDAC4HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105461705-A | Dibenzo-azepine-dione anti-tumor compounds and preparation method thereof | UNIV CHINA MEDICAL | 2016-04-06 | — | — | CN | claimed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| US-20230157978-A1 | APE/REF1 INHIBITORS FOR THE TREATMENT OF CANCER | CHAPMAN UNIVERSITY | 2023-05-25 | — | — | US | disclosed |
| WO-2022187849-A1 | SALINOMYCIN DERIVATIVES AND USES THEREOF | HILLSTREAM BIOPHARMA, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| WO-2022035763-A1 | BORON CONTAINING COMPOUNDS AND THEIR USES | 5METIS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
| WO-2022035763-A1 | BORON CONTAINING COMPOUNDS AND THEIR USES | 5METIS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
| CN-110684002-B | Acylhydrazone fluoride ion probe based on flavone | 南京林业大学 | 2022-02-08 | — | — | CN | disclosed |
| WO-2021055506-A1 | ANTIMICROBIAL AGENTS AND COMPOSITIONS AND USES THEREOF | CHEMIC LABORATORIES, INC. (US) | 2021-03-25 | — | — | WO | disclosed |
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2020264581-A1 | BORON CONTAINING COMPOUNDS AND THEIR USES | Boragen, Inc. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020264581-A1 | BORON CONTAINING COMPOUNDS AND THEIR USES | Boragen, Inc. (US) | 2020-12-30 | — | — | WO | disclosed |
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-20130165507-A1 | NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2013-06-27 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |
| WO-2012032257-A1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2012-03-15 | — | — | WO | disclosed |
| CN-1089755-C | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN SPA (IT) | 2002-08-28 | — | — | CN | disclosed |
| US-4065565-A | Acylhydrazones and anti-psychotic compositions thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-27 | — | — | US | disclosed |
| US-4065635-A | ETHYLENE-PROPYLENE COPOLYMER, DISUBSTITUTED HYDRAZINE | DART INDUSTRIES, INC. (US) | 1977-12-27 | — | — | US | disclosed |
| US-4052362-A | N-CINNAMOYL-N'-ACYLHYDRAZINES | UBE INDUSTRIES, LTD. (JA) | 1977-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165507-A1 | NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES | GMPS, UNG, AGER | HDAC2 3350/4885HDAC3 4240/4885HDAC4 3194/4885 |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | PGLS, RRS1, MRPL21 | HDAC2 4243/4885HDAC3 2208/4885HDAC4 3300/4885 |
| US-20230157978-A1 | APE/REF1 INHIBITORS FOR THE TREATMENT OF CANCER | APEX1, AP1G1, AP1M1 | HDAC2 1117/4885HDAC3 2293/4885HDAC4 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.