Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2753548 | 0.85 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL3138145 | 0.77 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL12460960 | 0.76 | NPC1 (0.84) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL3580813 | 0.73 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL3590753 | 0.72 | LMNA (0.64) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL10719011 | 0.67 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL4202353 | 0.67 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL14960416 | 0.66 | KMT2A (0.59) | RAB9ANPC1LMNAMEN1KMT2A | |
| SCHEMBL3584201 | 0.66 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2AHRLMNA | |
| SCHEMBL13015630 | 0.65 | KMT2A (0.58) | RAB9ANPC1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973169-B2 | including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), such as N-(4,5-Diphenyl-thiazol-2-yl)-benzamide, used for treating genetic disorders; respiratory system disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-05 | — | — | US | disclosed |