Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | ILK | Q13418 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17730627 | 0.98 | LMNA (0.58) | LMNAMAPTPIK3CAILKTDP1 | |
| SCHEMBL17730822 | 0.86 | LMNA (0.53) | LMNAMAPTPIK3CAILKKDM4E | |
| SCHEMBL24630701 | 0.82 | MAPT (0.60) | LMNAMAPTPIK3CATDP1KDM4E | |
| SCHEMBL102979 | 0.80 | EPHX2 (0.58) | LMNAILKKDM4EEPHX2GAA | |
| SCHEMBL17731303 | 0.80 | ILK (0.57) | PIK3CAILKKDM4ETGFBR1 | |
| SCHEMBL3472474 | 0.79 | LMNA (0.66) | LMNAMAPTPIK3CAILKTDP1 | |
| SCHEMBL16534777 | 0.77 | LMNA (0.68) | LMNAMAPTTDP1KDM4EEPHX2 | |
| SCHEMBL1248084 | 0.76 | LMNA (0.66) | LMNAMAPTPIK3CATDP1KDM4E | |
| SCHEMBL1245491 | 0.76 | LMNA (0.66) | LMNAMAPTTDP1KDM4EGAA | |
| SCHEMBL15020489 | 0.76 | MAPT (0.66) | LMNAMAPTTDP1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014520-A2 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-02-03 | — | — | WO | disclosed |