Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 1/20 | 0.38 |
| ▸ | GNB1 | P62873 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 8/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15388711 | 0.91 | GNG2 (0.38) | GNG2GNB1GSK3BNOTUMPTPN1 | |
| SCHEMBL12465677 | 0.81 | MCHR1 (0.32) | NOTUMMCHR1 | |
| SCHEMBL6335311 | 0.74 | NOTUM (0.59) | NOTUMALDH1A1 | |
| SCHEMBL12465927 | 0.73 | MCHR1 (0.33) | NOTUMALDH1A1MCHR1 | |
| SCHEMBL12620617 | 0.72 | GNG2 (0.53) | GNG2GNB1GSK3BPTPN1CYP3A4 | |
| SCHEMBL12465638 | 0.72 | NOTUM (0.36) | NOTUM | |
| SCHEMBL12620633 | 0.71 | CYP3A4 (0.49) | GNG2GNB1GSK3BPTPN1ALDH1A1 | |
| SCHEMBL1550094 | 0.71 | CYP3A4 (0.59) | ALDH1A1CYP3A4CYP26A1CYP26B1 | |
| SCHEMBL11988475 | 0.71 | NOTUM (0.42) | NOTUM | |
| SCHEMBL12465855 | 0.70 | RARB (0.44) | GSK3BNOTUMALDH1A1CYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-B1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LTD (IN) | 2015-05-27 | — | — | EP | disclosed |
| EP-2670744-B1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LTD (IN) | 2015-05-27 | — | — | EP | disclosed |
| EP-2670744-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | Lupin Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2013-11-21 | — | — | US | disclosed |
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2013-11-21 | — | — | US | disclosed |
| WO-2012104782-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310419-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | CHRNA7, CHRNE, CHRNA5 | GNG2 1600/4885GNB1 1505/4885GSK3B 386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.