Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.83 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465791 | 0.91 | RORC (1.00) | RORC | |
| SCHEMBL12467541 | 0.87 | RORC (0.64) | RORCROCK1CYP3A4PRKACAROCK2 | |
| SCHEMBL12465880 | 0.85 | RORC (0.64) | RORCROCK1CYP3A4PRKACA | |
| SCHEMBL12465776 | 0.78 | RORC (0.79) | RORC | |
| SCHEMBL12465808 | 0.78 | RORC (0.78) | RORC | |
| SCHEMBL12465767 | 0.78 | RORC (0.78) | RORC | |
| SCHEMBL12466032 | 0.78 | RORC (0.78) | RORC | |
| SCHEMBL12465707 | 0.76 | RORC (0.85) | RORC | |
| SCHEMBL12465863 | 0.76 | RORC (0.74) | RORC | |
| SCHEMBL12465749 | 0.76 | RORC (0.76) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012100732-A1 | RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS, COMPOSITION CONTAINING THEM AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2012-08-02 | — | — | WO | disclosed |