Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466193 | 0.82 | KDM5A (0.52) | DYRK1ACLK1KDM5AKDM4CKDM5B | |
| SCHEMBL1461900 | 0.81 | CCNT1 (0.55) | KDM5AKDM4CKDM5BCCNT1 | |
| SCHEMBL6122655 | 0.80 | CCNT1 (0.53) | DYRK1ACLK1KDM5AKDM4CKDM5B | |
| SCHEMBL1191606 | 0.78 | CCNT1 (0.64) | KDM5AKDM4CKDM5BKDRCCNT1 | |
| SCHEMBL12466070 | 0.78 | CCNT1 (0.69) | CCNT1CDK9 | |
| SCHEMBL12466282 | 0.77 | KDM5A (0.50) | DYRK1ACLK1KDM5AKDM4CKDM5B | |
| SCHEMBL1191651 | 0.76 | CCNT1 (0.68) | KDM5AKDM4CKDM5BMAP4K4GSK3B | |
| SCHEMBL27876840 | 0.74 | F2 (0.51) | KCNH3KDM4EGAA | |
| SCHEMBL6696141 | 0.74 | HPGD (0.60) | KDM5AKDM4CKDM5BHPGDFFAR1 | |
| SCHEMBL6229701 | 0.74 | HPGD (0.65) | HPGDFFAR1CDK2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |