Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 10/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29836457 | 0.83 | CYP1A2 (0.64) | CLK4CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL1666072 | 0.83 | CYP1A2 (0.64) | CLK4CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL5153294 | 0.77 | HRH4 (0.57) | CCNT1KDM5AKDM4CKDM5BCYP2D6 | |
| SCHEMBL2224393 | 0.77 | NTRK1 (0.45) | CLK4MAP4K4PTK2CYP1A2CYP3A4 | |
| SCHEMBL16654031 | 0.77 | CYP1A2 (0.67) | KDM4CCLK4JAK2JAK3DYRK1A | |
| SCHEMBL12466282 | 0.77 | KDM5A (0.50) | CCNT1KDM5AKDM4CKDM5BCLK4 | |
| SCHEMBL1192525 | 0.75 | BRAF (0.53) | CCNT1KDM5AKDM4CKDM5BSTIM1 | |
| SCHEMBL3948180 | 0.75 | CYP1A2 (0.48) | CLK4DYRK1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12466193 | 0.75 | KDM5A (0.52) | KDM5AKDM4CKDM5BCLK4AURKA | |
| SCHEMBL1192282 | 0.74 | CCNT1 (0.67) | CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |