Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466509 | 0.81 | KDM1A (0.42) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL6714534 | 0.80 | MAPT (0.49) | KDM1AKMT2APOLBRAD52ATM | |
| SCHEMBL12466786 | 0.80 | HDAC3 (0.42) | KDM1AKMT2APOLBRAD52ATM | |
| SCHEMBL12466719 | 0.76 | KDM1A (0.53) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL6712937 | 0.73 | MAOA (0.52) | KMT2AKDM4EMAPTMEN1GLA | |
| SCHEMBL15064543 | 0.72 | HDAC3 (0.37) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL15064545 | 0.72 | HDAC3 (0.37) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL15064587 | 0.71 | TP53 (0.37) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL15064588 | 0.71 | TP53 (0.37) | KDM1AKMT2APOLBRAD52GFER | |
| SCHEMBL15064551 | 0.71 | HDAC3 (0.36) | KDM1AKMT2APOLBRAD52GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952033-B2 | 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-02-10 | — | — | US | claimed |
| WO-2012102965-A1 | 4-ANILINOFURO[2,3-b]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (CN) | 2012-08-02 | — | — | WO | claimed |
| WO-2012102965-A1 | 4-ANILINOFURO[2,3-b]QUINOLINE DERIVATIVES, THEIR PREPARATION PROCESSES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (CN) | 2012-08-02 | — | — | WO | disclosed |