Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014847 | 0.75 | LMNA (0.73) | USP2NPSR1LMNAEPHX1EPHX2 | |
| SCHEMBL31562922 | 0.74 | LMNA (0.68) | USP2LMNAEPHX1EPHX2KCNH2 | |
| SCHEMBL12685846 | 0.72 | MEN1 (0.85) | NPSR1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL5014849 | 0.71 | LMNA (0.70) | USP2LMNAEPHX1EPHX2KCNH2 | |
| Hydrochloric Acid SCHEMBL12466326 | 0.71 | MEN1 (0.83) | NPSR1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6981315 | 0.70 | MEN1 (0.58) | USP2NPSR1ALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL12466738 | 0.70 | NPSR1 (0.54) | NPSR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12466436 | 0.69 | EPHX2 (0.63) | NPSR1EPHX2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL30772251 | 0.69 | LMNA (0.65) | USP2NPSR1LMNAEPHX1EPHX2 | |
| SCHEMBL27195865 | 0.69 | LMNA (0.65) | USP2NPSR1LMNAEPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | claimed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | claimed |
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | disclosed |