Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014847 | 0.82 | LMNA (0.73) | LMNAHTR2BALDH1A1EPHX1EPHX2 | |
| SCHEMBL26862272 | 0.80 | LMNA (0.60) | LMNAHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL13810503 | 0.80 | LMNA (0.61) | LMNAHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL21361595 | 0.80 | LMNA (0.61) | LMNAHTR2BMEN1KMT2AEPHX1 | |
| SCHEMBL31562922 | 0.79 | LMNA (0.68) | LMNAHTR2BALDH1A1EPHX1EPHX2 | |
| SCHEMBL4457699 | 0.77 | RAB9A (0.59) | LMNAHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL14895871 | 0.77 | LMNA (0.57) | LMNAHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL27969428 | 0.77 | BCHE (0.59) | LMNAHTR2BALDH1A1USP2 | |
| SCHEMBL21361620 | 0.76 | LMNA (0.57) | LMNAHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL1128181 | 0.76 | RAB9A (0.62) | LMNAHTR2BMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539261-B2 | Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration | NEURONASCENT, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150209371-A1 | Methods and Compositions For Stimulating Neurogenesis and Inhibiting Neuronal Degeneration | NEURONASCENT, INC. | 2015-07-30 | — | — | US | disclosed |
| US-8999972-B2 | Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration | NEURONASCENT, INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20110319391-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION | NEURONASCENT, INC. | 2011-12-29 | — | — | US | disclosed |
| US-20080234253-A1 | Methods and Compositons for Stimulating Neurogenesis and Inhibiting Neuronal Degeneration | NEURONASCENT, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1937252-A2 | METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION | Neuronascent, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007035722-A2 | METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION | NEURONASCENT, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319391-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION | DCX, BDNF, GAP43 | LMNA 1661/4885HTR2B 1397/4885MEN1 2489/4885 |
| US-20080234253-A1 | Methods and Compositons for Stimulating Neurogenesis and Inhibiting Neuronal Degeneration | DCX, BDNF, GAP43 | LMNA 991/4885HTR2B 1218/4885MEN1 1487/4885 |
| US-20150209371-A1 | Methods and Compositions For Stimulating Neurogenesis and Inhibiting Neuronal Degeneration | DCX, BDNF, GAP43 | LMNA 1661/4885HTR2B 1397/4885MEN1 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.