SCHEMBL12467260

SCHEMBL12467260

O=C(O)NCc1ccc(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(C(F)(F)F)C2)nc1Br

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 3/20 0.35
MCHR1 Q99705 1/20 0.35
CYP3A4 P08684 4/20 0.34
TSHR P16473 3/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
CYP2D6 P10635 2/20 0.34
CYP1A2 P05177 1/20 0.34
USP2 O75604 4/20 0.34
FFAR4 Q5NUL3 1/20 0.34
TRPV1 Q8NER1 6/20 0.33
OPRM1 P35372 5/20 0.33
SCD O00767 2/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807621 0.88 CACNA1H (0.40) TACR1MCHR1TSHRCYP2D6TRPV1
SCHEMBL799014 0.86 SCD (0.42) MCHR1CYP3A4TSHRSMN1; SMN2CYP2D6
SCHEMBL794132 0.84 SCD (0.35) MCHR1CYP3A4TSHRSMN1; SMN2CYP2D6
SCHEMBL12467053 0.83 CYP3A4 (0.33) TACR1MCHR1CYP3A4TSHRSMN1; SMN2
SCHEMBL794384 0.82 TACR1 (0.33) TACR1MCHR1CYP3A4TSHRSMN1; SMN2
SCHEMBL795686 0.82 NR1H2 (0.34) TACR1MCHR1CYP3A4TSHRSMN1; SMN2
SCHEMBL15474198 0.81 SCD (0.33) SCD
SCHEMBL795833 0.80 CYP1A2 (0.34) MCHR1CYP3A4TSHRSMN1; SMN2CYP2D6
SCHEMBL12467010 0.80 EPHX2 (0.40) TRPV1SCD
SCHEMBL793870 0.80 TSHR (0.40) MCHR1TSHRCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616437-A1 PESTICIDAL ARYLPYRROLIDINES Bayer Intellectual Property GmbH (DE) 2013-07-24 EP disclosed
WO-2012035011-A1 PESTICIDAL ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2012-03-22 WO disclosed