Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187343 | 0.84 | TSHR (0.49) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL2186976 | 0.84 | TP53 (0.54) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL11910559 | 0.78 | TLR7 (0.48) | ALDH1A1HIF1AHTTTP53MEN1 | |
| SCHEMBL12677951 | 0.78 | MAPT (0.56) | ALDH1A1HIF1AHTTTP53MEN1 | |
| SCHEMBL11910556 | 0.77 | HIF1A (0.57) | ALDH1A1TSHRHIF1AHTTMEN1 | |
| SCHEMBL11910534 | 0.75 | MAPT (0.47) | ALDH1A1HIF1AMEN1KMT2ATLR7 | |
| SCHEMBL13729834 | 0.74 | ALDH1A1 (0.52) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL11020367 | 0.74 | ALDH1A1 (0.53) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL13730143 | 0.71 | ALDH1A1 (0.52) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL1006444 | 0.71 | HTT (0.71) | ALDH1A1TSHRGLAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278969-A2 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010011375-A2 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |