Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672495 | 0.82 | GSK3B (0.38) | GSK3BKCNH2FLT3 | |
| SCHEMBL674039 | 0.76 | FLT3 (0.35) | GSK3BKCNH2ROCK1CDC42BPBFLT3 | |
| SCHEMBL672462 | 0.75 | GSK3B (0.36) | GSK3BKCNH2ROCK1CDC42BPBFLT3 | |
| SCHEMBL672461 | 0.73 | KCNH2 (0.36) | GSK3BKCNH2ROCK1CDC42BPBFLT3 | |
| SCHEMBL12468151 | 0.71 | KCNH2 (0.34) | GSK3BKCNH2ROCK1CDC42BPBADORA2B | |
| SCHEMBL672451 | 0.63 | PRKCI (0.35) | GSK3BKCNH2ROCK1CDC42BPB | |
| SCHEMBL674121 | 0.63 | GSK3B (0.36) | GSK3BKCNH2ROCK1CDC42BPB | |
| SCHEMBL674120 | 0.63 | MAP4K1 (0.35) | GSK3BKCNH2ROCK1CDC42BPBMAPK1 | |
| SCHEMBL20577255 | 0.62 | HTR3A (0.41) | KCNH2ROCK1CDC42BPB | |
| SCHEMBL20577257 | 0.62 | HTR3A (0.41) | KCNH2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |