Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NRAS | P01111 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672462 | 0.78 | GSK3B (0.36) | FLT3GSK3BROCK1CDC42BPBKCNH2 | |
| SCHEMBL12468308 | 0.76 | GSK3B (0.33) | FLT3GSK3BROCK1CDC42BPBKCNH2 | |
| SCHEMBL672461 | 0.76 | KCNH2 (0.36) | FLT3GSK3BROCK1CDC42BPBKCNH2 | |
| SCHEMBL672495 | 0.76 | GSK3B (0.38) | FLT3SYKGSK3BKCNH2PRKD1 | |
| SCHEMBL12468151 | 0.72 | KCNH2 (0.34) | GSK3BROCK1CDC42BPBKCNH2ADORA2B | |
| SCHEMBL23292474 | 0.68 | MAPK8 (0.44) | FLT3SYKAURKBNRASROCK1 | |
| SCHEMBL23292472 | 0.68 | MAPK8 (0.44) | FLT3SYKAURKBNRASROCK1 | |
| SCHEMBL672451 | 0.66 | PRKCI (0.35) | GSK3BROCK1CDC42BPBKCNH2PRKCI | |
| SCHEMBL674120 | 0.66 | MAP4K1 (0.35) | GSK3BROCK1CDC42BPBKCNH2ADORA2B | |
| SCHEMBL674121 | 0.66 | GSK3B (0.36) | GSK3BROCK1CDC42BPBKCNH2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |