Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604635 | 0.83 | CYP4A11 (0.54) | DAOPARP1POLBSMN1; SMN2KDM4E | |
| SCHEMBL15135063 | 0.83 | HSD17B10 (0.51) | LTB4RDAORXFP1HSD17B10POLB | |
| SCHEMBL2331028 | 0.81 | DAO (0.47) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL2176203 | 0.80 | PARP1 (0.47) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL4083604 | 0.79 | PARP1 (0.46) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL13814173 | 0.77 | DAO (0.65) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL9849816 | 0.76 | LMNA (0.40) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL24036135 | 0.76 | PARP1 (0.49) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL2173402 | 0.76 | PARP1 (0.46) | DAOPARP1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL12407032 | 0.76 | LOXL2 (0.49) | DAOPARP1HSD17B10POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627332-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051105-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-04-19 | — | — | WO | disclosed |