Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SCN4A | P35499 | 2/20 | 0.62 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271389 | 0.85 | NPC1 (0.62) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL3091070 | 0.81 | NPC1 (0.69) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL7542512 | 0.80 | CYP1A2 (0.59) | CYP3A4NPC1RAB9ACYP1A2GAA | |
| SCHEMBL25244908 | 0.78 | KMT2A (0.43) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL29486946 | 0.78 | KMT2A (0.43) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL20511690 | 0.78 | CYP1A2 (0.56) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL2665688 | 0.77 | NPC1 (0.68) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL3695300 | 0.77 | NPC1 (0.68) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| SCHEMBL1748078 | 0.77 | NPC1 (0.68) | CYP3A4NPC1RAB9ASCN4ASCN9A | |
| Riluzole SCHEMBL78905 | 0.77 | RAB9A (1.00) | CYP3A4NPC1RAB9ASCN4ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759382-B2 | Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2014-06-24 | — | — | US | disclosed |
| US-8759382-B2 | Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2014-06-24 | — | — | US | disclosed |
| EP-2621490-A2 | PROPARGYL-TRIFLUOROMETHOXY-AMINOBENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE | Teva Pharmaceutical Industries Ltd. (IL) | 2013-08-07 | — | — | EP | disclosed |
| US-20130172364-A1 | PROPARGYL-TRIFLUOROMETHOXY-AMINOBENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2013-07-04 | — | — | US | disclosed |
| US-20130172364-A1 | PROPARGYL-TRIFLUOROMETHOXY-AMINOBENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2013-07-04 | — | — | US | disclosed |
| WO-2012050971-A2 | PROPARGYL-TRIFLUOROMETHOXY-AMINOBENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172364-A1 | PROPARGYL-TRIFLUOROMETHOXY-AMINOBENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE | PARK7, SNCA, PMP22 | CYP3A4 2342/4885NPC1 2744/4885RAB9A 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.