Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12685439 | 1.00 | HSD11B1 (0.41) | HSD11B1PRKCQS1PR1OGFRL1KDR | |
| SCHEMBL12685434 | 1.00 | HSD11B1 (0.41) | HSD11B1PRKCQS1PR1OGFRL1KDR | |
| SCHEMBL12469347 | 0.96 | HSD11B1 (0.42) | HSD11B1PRKCQS1PR1OGFRL1KDR | |
| SCHEMBL12469060 | 0.84 | FLT3 (0.42) | HSD11B1PRKCQIRAK4CA12CA1 | |
| SCHEMBL12468994 | 0.83 | NAMPT (0.39) | HSD11B1PRKCQIRAK4CA12CA1 | |
| SCHEMBL12469124 | 0.83 | NAMPT (0.39) | HSD11B1PRKCQIRAK4CA12CA1 | |
| SCHEMBL19222529 | 0.79 | HSD11B1 (0.37) | HSD11B1PRKCQOGFRL1HRH3IRAK4 | |
| SCHEMBL19222456 | 0.79 | HSD11B1 (0.37) | HSD11B1PRKCQOGFRL1HRH3IRAK4 | |
| SCHEMBL15347563 | 0.77 | HSD11B1 (0.50) | HSD11B1KDRHRH3ALDH1A1LMNA | |
| SCHEMBL30077118 | 0.77 | HSD11B1 (0.50) | HSD11B1KDRHRH3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627649-A1 | CXCR4 RECEPTOR ANTAGONISTS | Proximagen Limited (GB) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012049277-A1 | CXCR4 RECEPTOR ANTAGONISTS | PROXIMAGEN LTD (GB) | 2012-04-19 | — | — | WO | disclosed |