SCHEMBL12469157

SCHEMBL12469157

O=C1CNCc2ccncc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.41
CHRNA4 P43681 2/20 0.41
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
CDC25B P30305 1/20 0.37
SIGMAR1 Q99720 1/20 0.36
MKNK2 Q9HBH9 2/20 0.35
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
PDE3B Q13370 3/20 0.34
PDE3A Q14432 3/20 0.34
TIPARP Q7Z3E1 1/20 0.32
CYP11B1 P15538 2/20 0.32
CYP11B2 P19099 2/20 0.32
PKN1 Q16512 1/20 0.32
PKN2 Q16513 1/20 0.32
CYP1A2 P05177 1/20 0.32
CDC7 O00311 1/20 0.31
CYP19A1 P11511 1/20 0.31
TP53 P04637 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27977467 0.85 CHRNB2 (0.41) CHRNB2CHRNA4MAOAMAOBCDC25B
SCHEMBL148437 0.76 CA12 (0.55) CHRNB2CHRNA4MAOAMAOBCDC25B
SCHEMBL1118591 0.74
SCHEMBL29378632 0.74
Hydrochloric Acid SCHEMBL7086048 0.74 CA12 (0.53) CHRNB2CHRNA4MAOAMAOBCDC25B
SCHEMBL30082317 0.74 CYP11B2 (0.49) CHRNB2CHRNA4MAOAMAOBCDC25B
SCHEMBL3581879 0.74 CYP11B2 (0.49) CHRNB2CHRNA4MAOAMAOBCDC25B
Hydrochloric Acid SCHEMBL9317481 0.73 CHRNB2 (0.54) CHRNB2CHRNA4MAOBSIGMAR1PDE3B
Hydrochloric Acid SCHEMBL793721 0.73 CHRNB2 (0.54) CHRNB2CHRNA4MAOBSIGMAR1PDE3B
Hydrochloric Acid SCHEMBL16637919 0.73 CHRNB2 (0.54) CHRNB2CHRNA4MAOBSIGMAR1PDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2627648-A1 17aHYDROXYLASE/C17,20-LYASE INHIBITORS Novartis AG (CH) 2013-08-21 EP disclosed
WO-2012035078-A1 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 WO disclosed