Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RGS12 | O14924 | 2/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712158 | 0.86 | HSPB1 (0.51) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL25200788 | 0.82 | HSPB1 (0.59) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL4715000 | 0.77 | MAPT (0.57) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL4715002 | 0.77 | MAPT (0.57) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL4714612 | 0.76 | HSPB1 (0.68) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL10983574 | 0.76 | HSPB1 (0.55) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL1980920 | 0.76 | HSPB1 (0.55) | MAPTSMN1; SMN2LMNAHTTHSPB1 | |
| SCHEMBL1851173 | 0.75 | KMT2A (0.70) | MAPTHTTHSPB1MEN1KMT2A | |
| SCHEMBL30850667 | 0.75 | KMT2A (0.70) | MAPTHTTHSPB1MEN1KMT2A | |
| SCHEMBL27449389 | 0.75 | HSPB1 (0.70) | MAPTSMN1; SMN2LMNAHTTHSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2624833-A1 | 4- (METHYLAMINOPHENOXY) PYRDIN- 3 - YL - BENZAMIDE DERIVATIVES FOR TREATING CANCER | Otsuka Pharmaceutical Co., Ltd. (JP) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012046825-A1 | 4- (METHYLAMINOPHENOXY) PYRDIN- 3 - YL - BENZAMIDE DERIVATIVES FOR TREATING CANCER | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-12 | — | — | WO | disclosed |