Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.74 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901307 | 0.94 | KARS1 (0.77) | KARS1SYKNPC1MAPTHTT | |
| SCHEMBL1755683 | 0.85 | KARS1 (1.00) | KARS1SYKCDK1NPC1MAPT | |
| SCHEMBL901241 | 0.85 | KARS1 (1.00) | KARS1SYKCDK1NPC1MAPT | |
| SCHEMBL1704304 | 0.84 | KARS1 (0.72) | KARS1SYKCDK1NPC1MAPT | |
| SCHEMBL901741 | 0.84 | KARS1 (0.74) | KARS1SYKNPC1MAPTHTT | |
| SCHEMBL10268092 | 0.83 | KARS1 (1.00) | KARS1SYKNPC1RAB9AMEN1 | |
| SCHEMBL901754 | 0.82 | KARS1 (0.58) | KARS1CDK1NPC1MAPTHTT | |
| SCHEMBL12469132 | 0.82 | KARS1 (0.72) | KARS1SYKNPC1MAPTHTT | |
| SCHEMBL901879 | 0.82 | KARS1 (0.71) | KARS1SYKCDK1NPC1MAPT | |
| SCHEMBL1704345 | 0.82 | KARS1 (0.59) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |