SCHEMBL12469638

SCHEMBL12469638

C=C(COC(=O)c1c(Cl)cccc1Cl)C(=O)NC(CC(C)C)C(=O)NCC(=O)OCC

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TXNRD1 Q16881 1/20 0.49
HTT P42858 1/20 0.43
CASP3 P42574 12/20 0.41
CASP6 P55212 11/20 0.41
CASP8 Q14790 11/20 0.41
CTSS P25774 1/20 0.39
ANPEP P15144 2/20 0.38
NLRP3 Q96P20 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12469640 0.88 TXNRD1 (0.48) TXNRD1HTTCASP3CASP6CASP8
SCHEMBL12469670 0.87 TXNRD1 (0.52) TXNRD1HTTCTSS
SCHEMBL16628784 0.87 TXNRD1 (0.52) TXNRD1HTTCTSS
SCHEMBL12469706 0.87 TXNRD1 (0.52) TXNRD1HTTCTSS
SCHEMBL12470033 0.76 CAPN9 (0.40) CTSS
SCHEMBL12469773 0.76 CAPN9 (0.40) CTSS
SCHEMBL12469672 0.76 TXNRD1 (0.52) TXNRD1HTTCTSS
SCHEMBL16628812 0.75 CAPN9 (0.42) CTSS
SCHEMBL16628809 0.75 CAPN9 (0.42) CTSS
SCHEMBL16628790 0.75 CAPN9 (0.42) CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2627628-B1 NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM INST CHEMII ORGANICZNEJ POLSKIEJ AKADEMII NAUK (PL) 2015-04-15 EP claimed
EP-2627628-A1 NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM Instytut Chemii Fizycznej Polskiej Akademii Nauk (PL) 2013-08-21 EP claimed
WO-2012050465-A1 NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM Instytut Chemii Organicznej Polskiej Akademii Nauk (PL) 2012-04-19 WO claimed
EP-2627628-A1 NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM Instytut Chemii Fizycznej Polskiej Akademii Nauk (PL) 2013-08-21 EP disclosed
WO-2012050465-A1 NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM Instytut Chemii Organicznej Polskiej Akademii Nauk (PL) 2012-04-19 WO disclosed