Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669802 | 0.90 | TSHR (0.57) | ALDH1A1TSHRNFE2L2LMNAFBP1 | |
| SCHEMBL6328580 | 0.85 | NFE2L2 (0.58) | ALDH1A1TSHRNFE2L2LMNAFBP1 | |
| SCHEMBL8670587 | 0.81 | CYP19A1 (0.48) | ALDH1A1CYP19A1TDP1NPC1 | |
| SCHEMBL6376999 | 0.79 | CYP19A1 (0.61) | ALDH1A1TSHRNFE2L2LMNAFBP1 | |
| SCHEMBL13622505 | 0.79 | NFE2L2 (0.72) | ALDH1A1TSHRNFE2L2LMNAFBP1 | |
| SCHEMBL287236 | 0.76 | TSHR (0.65) | ALDH1A1TSHRNFE2L2LMNAMEN1 | |
| 3-Nitroaniline SCHEMBL1487 | 0.76 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNAKMT2ATDP1 | |
| 3-Nitroaniline SCHEMBL29364768 | 0.76 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNAKMT2ATDP1 | |
| SCHEMBL3718150 | 0.75 | TSHR (0.62) | ALDH1A1TSHRNFE2L2LMNAMEN1 | |
| SCHEMBL9452244 | 0.74 | TSHR (0.57) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2672822-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109491-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-16 | — | — | WO | disclosed |