Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30575119 | 0.98 | HSP90AA1 (0.39) | HSP90AA1P2RX7KDM4ECYP3A4ALOX12 | |
| SCHEMBL29080505 | 0.98 | HSP90AA1 (0.39) | HSP90AA1P2RX7KDM4ECYP3A4ALOX12 | |
| SCHEMBL13134209 | 0.82 | ELANE (0.38) | HSP90AA1P2RX7TDP1LMNAKMT2A | |
| SCHEMBL3657194 | 0.82 | HSP90AA1 (0.41) | HSP90AA1P2RX7KMT2AHSD17B10CTNNB1 | |
| SCHEMBL6648327 | 0.81 | P2RX7 (0.41) | HSP90AA1P2RX7KDM4ECYP3A4LMNA | |
| SCHEMBL2788170 | 0.80 | P2RX7 (0.43) | HSP90AA1P2RX7KDM4EKMT2AHSD17B10 | |
| SCHEMBL8390998 | 0.80 | HSP90AA1 (0.45) | HSP90AA1P2RX7KDM4ECYP3A4TDP1 | |
| SCHEMBL20334077 | 0.79 | ELANE (0.41) | HSP90AA1P2RX7TDP1BRAFKDR | |
| SCHEMBL30606641 | 0.79 | ELANE (0.43) | HSP90AA1P2RX7KDM4EKMT2AMAPT | |
| SCHEMBL30606626 | 0.79 | KMT2A (0.40) | HSP90AA1P2RX7CYP3A4LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443099-B | Regulate composition and the method for FXR | NOVARTIS AG (CH) | 2016-03-23 | — | — | CN | claimed |
| CN-104870449-A | Novel compounds | CHIESI FARMA SPA | 2015-08-26 | — | — | CN | claimed |
| CN-103827117-A | Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors | CHIESI FARMA SPA | 2014-05-28 | — | — | CN | claimed |
| US-20140128373-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2014-05-08 | — | — | US | claimed |
| CN-103517710-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2014-01-15 | — | — | CN | claimed |
| CN-103443099-A | Compositions and methods for modulating FXR | IRM LLC | 2013-12-11 | — | — | CN | claimed |
| CN-1407985-A | Heterocyclic dihydropyrimidines as potassium channel inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2003-04-02 | — | — | CN | claimed |
| US-20230277534-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2023-09-07 | — | — | US | disclosed |
| CN-116568301-A | Bicyclic compounds for treating diseases and uses thereof | 雅斯娜制药公司 | 2023-08-08 | — | — | CN | disclosed |
| US-11337976-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2022-05-24 | — | — | US | disclosed |
| EP-2672967-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-20170157120-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2017-06-08 | — | — | US | disclosed |
| US-9624213-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-04-18 | — | — | US | disclosed |
| CN-101360719-A | 2- (polysubstituted aryl) -6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2009-02-04 | — | — | CN | disclosed |
| CN-101163693-A | Antibacterial piperidine derivatives | ASTRAZENECA AB (SE) | 2008-04-16 | — | — | CN | disclosed |
| CN-100371329-C | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases | AVENTIS PHARMA GMBH (DE) | 2008-02-27 | — | — | CN | disclosed |
| CN-101023063-A | Azine-carboxamides as anti-cancer agents | ASTRAZENECA AB (SE) | 2007-08-22 | — | — | CN | disclosed |
| CN-1714083-A | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases | AVENTIS PHARMA GMBH (DE) | 2005-12-28 | — | — | CN | disclosed |
| CN-1422268-A | 5-alkylpyrido [2,3-D] pyrimidines tyrosine kinase inhibitors | WARNER LAMBERT CO (US) | 2003-06-04 | — | — | CN | disclosed |
| CN-1407985-A | Heterocyclic dihydropyrimidines as potassium channel inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2003-04-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11337976-B2 | Compounds and methods for kinase modulation, and indications therefor | MAP3K20, PRKACA, MAP3K13 | HSP90AA1 583/4885P2RX7 3830/4885KDM4E 2174/4885 |
| US-20230277534-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, PRKACA, MAP3K13 | HSP90AA1 583/4885P2RX7 3830/4885KDM4E 2174/4885 |
| US-20140128373-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, PRKACA, MAP3K13 | HSP90AA1 583/4885P2RX7 3830/4885KDM4E 2174/4885 |
| US-20170157120-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, PRKACA, MAP3K13 | HSP90AA1 583/4885P2RX7 3830/4885KDM4E 2174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.