Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1428236 | 0.82 | — | — | |
| SCHEMBL157427 | 0.82 | CYP2D6 (0.33) | — | |
| SCHEMBL3658217 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL10891279 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL6050828 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL2229452 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL4712511 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL2569149 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL286072 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL8640560 | 0.80 | CYP2D6 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2672967-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109075-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-08-16 | — | — | WO | disclosed |