Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GCG | P01275 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11899869 | 0.85 | MAPT (0.47) | RAB9AMAPTLMNAGCGKDM4E | |
| SCHEMBL12470856 | 0.83 | POLB (0.55) | POLBMAPTLMNAGCGTSHR | |
| SCHEMBL12471219 | 0.79 | GCG (0.44) | POLBTOP2AMAPTGCGKDM4E | |
| SCHEMBL11397372 | 0.77 | TSHR (0.61) | POLBRAB9AMAPTLMNATDP1 | |
| SCHEMBL11901124 | 0.77 | CA12 (0.53) | RAB9ALMNATDP1HPGDMAPK1 | |
| SCHEMBL381076 | 0.77 | POLB (0.53) | POLBTOP2ARAB9AMAPTLMNA | |
| SCHEMBL9829525 | 0.75 | MAPT (0.53) | POLBTOP2ARAB9AMAPTLMNA | |
| SCHEMBL11020358 | 0.74 | TOP2A (0.50) | POLBTOP2AMAPTLMNATDP1 | |
| SCHEMBL9830217 | 0.74 | MAPT (0.55) | POLBTOP2AMAPTLMNATDP1 | |
| SCHEMBL13196370 | 0.73 | TOP2A (0.49) | POLBTOP2AMAPTLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673260-A1 | GLUCAGON RECEPTOR MODULATOR | Pfizer Inc (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012107850-A1 | GLUCAGON RECEPTOR MODULATOR | PFIZER INC. (US) | 2012-08-16 | — | — | WO | disclosed |